Background There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs).The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood.Aims To determine the association between gestational vitamin 12N D status and ASD.Method Based on a birth coh
Plain English summary Adverse childhood experiences (ACEs) and other traumatic experiences commonly occur in the great majority of individuals with EDs.The mechanisms by which ACEs and EDs emerge and interact with each other to lead to Molded Fiber / Container early death is reviewed from the perspective of the ACEs pyramid and the escalating casca
Advances in the Blessed Thistle field chronobiology have potential implications for physical as well as mental health and human behavior.Several paradigm-shifting discoveries established key mechanistic principles for the biological clock.We trace the origins and key discoveries that helped to advance the field of chronobiology and a ground-breakin
High carbohydrate, low fat diets decrease plasma low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB) mass in normal subjects and in patients with familial hypercholesterolemia (FH).To investigate the mechanisms for these effects, four normal, four FH heterozygous, and one FH homozygous subjects were studied on a basal (45% carbo
In this article, we provide detailed protocols on using optogenetic dimerizers to acutely perturb activities of guanine nucleotide exchange factors (GEFs) specific to Ras, Rac or Rho small GTPases of the migratory networks in various mammalian and amoeba cell lines.These GEFs are crucial components of signal transduction networks which link upstrea